Asia Business Newsweekly
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Separation Science
Researchers at Shenyang Pharmaceutical University have published new data on separation science
April 14th, 2008
"A new and accurate HPLC method using sulfobutylether-beta-cyclodextrin (SBE-beta-CD) as chiral mobile phase additive (CMPA) was developed and validated for the determination of R-(+)pantoprazole in S-(-)pantoprazole. The influences of type and concentration of CD, ACN content and buffer pH of mobile phase on the resolution and retention of enantiomers were investigated," scientists in Shenyang, People's Republic of China report. "A baseline resolution of pantoprazole enantiomers was achieved on a Spherigel C18 column (150 min x 4.6 mm, 5 mu m) using ACN and 10 mM phosphate buffer (pH 2.5) containing 10 mM SBE-beta-CD (15:85 v/v) as mobile phase with a flow rate of 0.9...
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Source: Asia Business Newsweekly (2008-04-14)
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