Chemicals and Chemistry
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Analytical Chemistry
Research data from R. Tuytten and colleagues update understanding of analytical chemistry
May 15th, 2009
"The present paper introduces the use of a weak cation-exchange/crown ether column in the proteomics field. The 18-crown-6 ether functionality is well-known to selectively complex ammonium and monoalkylammonium, ions, which should make this column highly suitable to trap peptides with free alpha-NH2 or free epsilon-NH2 groups from lysine side chains," scientists in Belgium report. "This unique selection mechanism was put to the test in an N-teromics setup which aims for the enrichment of deliberately acetylated protein N-terminal peptides from a serum digest. It was demonstrated that peptides with free alpha-NH2 groups and peptides with alpha-amino-acetylated groups can be...
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Source: Chemicals and Chemistry (2009-05-15)
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