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Researchers from Children's Hospital Publish Findings in Osteosarcomas
July 12th, 2011
Scientists discuss in "Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression" new findings in Osteosarcomas. According to the authors of recent research from Boston, United States, "The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma (OS), an aggressive bone tumor with poor prognosis that often metastasizes to lung."
"On the basis of these observations, we examined the status of WWOX in human OS specimens and cell lines. In human OS clinical samples, WWOX expression was absent or...
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Source: Ivy League Week (2011-07-12)